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buprenorphine subdermal implant and pentobarbital both raise sedation. Stay clear of or Use Alternate Drug. Restrict use to people for whom option remedy choices are inadequatepentobarbital will lessen the level or effect of suvorexant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. Solid CYP3A4 inducers may well lower